General Information

  • ID:  hor004454
  • Uniprot ID:  P86597
  • Protein name:  Tachykinin-related peptide 4
  • Gene name:  NA
  • Organism:  Pyrrhocoris apterus (Sap sucking bug) (Cimex apterus)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  Expressed in the antennal lobe (at protein level).
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pyrrhocoris (genus), Pyrrhocoridae (family), Pyrrhocoroidea (superfamily), Pentatomomorpha (infraorder), Panheteroptera, Neoheteroptera, Euheteroptera, Heteroptera (suborder), Prosorrhyncha, Hemiptera (order), Paraneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  TPASGFFGMR
  • Length:  10(1-10)
  • Propeptide:  TPASGFFGMR
  • Signal peptide:  NA
  • Modification:  T10 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004454_AF2.pdbhor004454_ESM.pdb

Physical Information

Mass: 123093 Formula: C48H71N13O13S
Absent amino acids: CDEHIKLNQVWY Common amino acids: FG
pI: 10.55 Basic residues: 1
Polar residues: 4 Hydrophobic residues: 3
Hydrophobicity: 9 Boman Index: -889
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 10
Instability Index: 2072 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  19084564
  • Title:  Neuropeptides in Heteroptera: Identification of Allatotropin-Related Peptide and Tachykinin-Related Peptides Using MALDI-TOF Mass Spectrometry